[Complex assessment of esophageal acidification and motor function in patients with Barrett's esophagus on antisecretory therapy].

Abstract

AIM:

To determine predictors of insufficient effectiveness of proton pump inhibitors based on the parameters of 24-hours pH-impedance and features of motor function of the esophagus in patients with Barrett's esophagus.

MATERIALS AND METHODS:

17 patients with histologically verified Barrett's esophagus undergoing acid-suppressive therapy were examined. All patients underwent 24-hours pH-impedance and high-resolution esophageal manometry.

RESULTS:

According to daily pH-impedance, group 1 consisted of 11 patients with an adequate response to antisecretory therapy, group 2 6 patients with insufficient effectiveness of antisecretory therapy, 5 of whom had no clinical manifestations. The total number of reflux averaged 52 and 91, respectively, in groups 1 and 2. The average number of acid reflux in group 1 was 4.36, in group 2 40.5. The average number of non-acid reflux prevailed in patients of group 2, averaging 58, compared with group 1, where the average was 47. According to the results of high-resolution esophageal manometry, when assessing the structure and function of the esophageal-gastric junction, violations were detected in 6 out of 17 patients. Disorders of the motor function of the thoracic esophagus were detected in 10 out of 17 patients. The tone of the lower esophageal sphincter in group 1 patients was significantly higher in comparison with patients in group 2.

CONCLUSION:

A number of patients with Barrett's esophagus have insufficient effectiveness of antisecretory therapy, which may not manifest itself clinically and thereby increase the risk of progression. There was a tendency to more frequent motor disorders in the group with insufficient effectiveness of antisecretory therapy, as well as significantly lower tone of the lower esophageal sphincter, which may be a potential predictor of suboptimal effectiveness of antisecretory therapy.

• Authors: I V Maev, E V Barkalova, D N Andreev, M A Ovsepian, P R Movtaeva, O V Zayratyants
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 93 Issue 12 Pg. 1463-1469 (Dec 15 2021) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 36286674 (Publication Type: English Abstract, Journal Article)

Chemical References

• Proton Pump Inhibitors

Topics

• Humans
• Barrett Esophagus (diagnosis, drug therapy, pathology)
• Proton Pump Inhibitors (therapeutic use)
• Esophagitis, Peptic
• Gastroesophageal Reflux (diagnosis, drug therapy)
• Hydrogen-Ion Concentration