Detection of a Highly Divergent Type 3 Vaccine-Derived Poliovirus in a Child with a Severe Primary Immunodeficiency Disorder - Chongqing, China, 2022.
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| Abstract |
Oral poliovirus vaccine (OPV) has proven to be highly effective in the global effort to eradicate poliomyelitis because of its ability to induce both humoral and intestinal immunity, ease of administration, and low cost (1). Sabin-strain OPV contains live attenuated virus and induces immunity by replicating in the intestinal tract, triggering an immune response that clears the vaccine virus. However, among undervaccinated communities and persons with immunodeficiency, OPV mutations that arise during prolonged replication can result in the emergence of genetically divergent, neurovirulent vaccine-derived polioviruses (VDPVs). In addition, OPV has resulted in rare cases of vaccine-associated paralytic poliomyelitis (VAPP) among vaccine recipients or their close contacts (1). Identification of circulating polioviruses relies on surveillance of acute flaccid paralysis (AFP) and environmental surveillance of wastewater (i.e., sewage). In 2022, type 3 VDPV (VDPV3) was detected in stool specimens from an infant with primary immunodeficiency disorder (PID) through a pilot surveillance program to identify VDPVs in children with PIDs. Integrated AFP, environmental, and immunodeficiency-associated VDPV (iVDPV) surveillance is critical to detecting and containing all polioviruses and achieving the goal of global polio eradication.
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| Authors | Ning Yao, Yang Liu, Jia-Wei Xu, Qing Wang, Zun-Dong Yin, Ning Wen, Hong Yang, Lance E Rodewald, Zhi-Yong Zhang |
| Journal | MMWR. Morbidity and mortality weekly report (MMWR Morb Mortal Wkly Rep) Vol. 71 Issue 36 Pg. 1148-1150 (Sep 09 2022) ISSN: 1545-861X [Electronic] United States |
| PMID | 36074738 (Publication Type: Case Reports, Journal Article) |
| Chemical References |
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