Compared to normal tissues and cells, the metabolic patterns of
tumor illnesses are more complex, and there are hallmarks of metabolic reprogramming in energy metabolism, lipid metabolism, and
amino acid metabolism. When
tumor cells are in a state of fast growth, they are susceptible to food shortage, resulting in growth suppression. Using this metabolic sensitivity of
tumor cells to construct
amino acid consumption
therapy does not harm the function of normal cells, which is the focus of metabolic
therapy research at the moment. As a non-
essential amino acid,
arginine is involved in numerous crucial biological processes, including the signaling system, cell proliferation, and material metabolism. Rapidly dividing
tumor cells are more likely to be deficient in
arginine; hence, utilizing
arginase to consume
arginine can suppress
tumor growth. Due to the absence of
arginine succinate synthase,
arginine succinate lyase, and
ornithine carbamoyl transferase in some blood
tumors, arginases may be employed to treat blood
tumors. By investigating the mechanism of
arginase treatment and the mechanism of drug resistance in greater depth,
arginase treatment becomes more successful in hematological
cancers and a new anti-
cancer agent in clinical practice.