Abstract | BACKGROUND:
Ewing sarcoma is one of the most frequent soft-tissue tumors in pediatric patients. The current treatment protocols recommend stem cell apheresis (SCA) after completion of the second course of induction therapy with vincristine, ifosfamide, doxorubicine, and etoposide (VIDE). The feasibility of SCA and graft compositions in adult patients with Ewing sarcoma have not been previously analyzed. METHODS AND MATERIALS: RESULTS: Median CD34+ cells/μL in peripheral blood before SCA were 45.8 (range 6.7-614.4)/μL. The median cumulative yields were 10.6 (range 1.5-38.8) CD34+ cells/kg body weight and ≥2×106 in all but two patients (89%). CD34, CD3, and CD56 yields in collections after the third VIDE and after later courses did not differ. Four patients underwent high-dose therapy with autologous transplantation, and all were engrafted. DISCUSSION:
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Authors | Georg-Nikolaus Franke, Roald Pfannes, Simone Heyn, Mandy Brückner, Susanne Rieprecht, Enrica Bach, Yvonne Remane, Sabine Leiblein, Wolfram Pönisch, Dietger Niederwieser, Sebastian Schwind, Uwe Platzbecker, Madlen Jentzsch, Vladan Vucinic |
Journal | Transfusion
(Transfusion)
Vol. 62
Issue 8
Pg. 1612-1618
(08 2022)
ISSN: 1537-2995 [Electronic] United States |
PMID | 35801531
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB. |
Chemical References |
- Antigens, CD34
- Granulocyte Colony-Stimulating Factor
- Vincristine
- Etoposide
- Doxorubicin
- Ifosfamide
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Topics |
- Adult
- Antigens, CD34
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Body Weight
- Child
- Doxorubicin
(adverse effects)
- Etoposide
- Female
- Granulocyte Colony-Stimulating Factor
(therapeutic use)
- Hematopoietic Stem Cell Mobilization
(methods)
- Hematopoietic Stem Cell Transplantation
- Humans
- Ifosfamide
(adverse effects)
- Male
- Middle Aged
- Sarcoma, Ewing
(drug therapy, etiology)
- Stem Cells
- Vincristine
(adverse effects, therapeutic use)
- Young Adult
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