Successful treatment of laryngeal leukoplakia by photodynamic therapy with local application of 5-aminolevulinic acid and 635 nm laser: A case report.

Abstract

Laryngeal leukoplakia is a common disorder in otolaryngology. Presently, the most widely accepted treatment is suspension laryngoscopic surgery under general anesthesia. The high recurrence rate and hoarse voice after surgery make it an intractable disease to treat. Here we report a case of a 67-year-old man who was diagnosed of laryngeal leukoplakia 15 years ago and underwent 5 surgeries because of its repeated recurrences. Two sessions of photodynamic therapy were performed with local application of 5-aminolevulinic acid and irradiation of 635 nm diode laser. Complete response was observed and no recurrence was detected during follow-up of 6 months. Photodynamic therapy with local 5-ALA application and 635 nm laser is safe and well-tolerated. It is a promising modality for laryngeal leukoplakia.

• Authors: Chi Zhang, Qian Hou, Hui Ren, Gelin Li
• Journal: Photodiagnosis and photodynamic therapy (Photodiagnosis Photodyn Ther) Vol. 39 Pg. 102999 (Sep 2022) ISSN: 1873-1597 [Electronic] Netherlands
• PMID: 35793782 (Publication Type: Case Reports)
• Copyright: Copyright © 2022. Published by Elsevier B.V.

Chemical References

• Photosensitizing Agents
• Aminolevulinic Acid

Topics

• Aged
• Aminolevulinic Acid (therapeutic use)
• Humans
• Laryngoscopy
• Laser Therapy
• Lasers
• Leukoplakia (drug therapy)
• Male
• Photochemotherapy (methods)
• Photosensitizing Agents (therapeutic use)