Effect of equipotent doses of propofol and sevoflurane on endoplasmic reticulum stress during breast cancer surgery.

Abstract

BACKGROUND:

Numerous studies suggest that intravenous propofol is superior to inhaled volatile anesthetic. This study compared the changes in the endoplasmic reticulum (ER) stress of cancer cells and lymphocytes after propofol- and sevoflurane-based anesthesia during breast cancer surgery.

METHODS:

We randomized 53 patients undergoing breast cancer surgery to propofol (n = 28) and sevoflurane (n = 25) anesthesia groups. Blood samples were obtained immediately before inducing anesthesia, and 1 and 24 h postoperatively. Human breast cancer cell lines were cultured and treated with patient plasma, and the frequency of C/EBP homologous protein (CHOP) on the cancer cell lines and lymphocytes was measured. The neutrophil-to-lymphocyte ratio in plasma was evaluated in both groups.

RESULTS:

The CHOP expression on breast cancer cell lines did not differ between the groups (P = 0.108), although it decreased significantly over time (P = 0.027). The CHOP expression on lymphocytes was comparable between the groups (P = 0.485), and was the neutrophil-to-lymphocyte ratio (P = 0.501).

CONCLUSIONS:

Propofol-based anesthesia did not induce greater ER stress than sevoflurane-based anesthesia during breast cancer surgery. The ER stress of cancer cells did not differ according to the type of anesthesia during breast cancer surgery.

• Authors: Chung-Sik Oh, Seung Wan Hong, Sarah Park, Yubi Kwon, Seong-Hyop Kim
• Journal: Korean journal of anesthesiology (Korean J Anesthesiol) Vol. 75 Issue 6 Pg. 487-495 (12 2022) ISSN: 2005-7563 [Electronic] Korea (South)
• PMID: 35760393 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Sevoflurane
• Propofol

Topics

• Humans
• Female
• Sevoflurane
• Propofol
• Breast Neoplasms (surgery)
• Endoplasmic Reticulum Stress
• Mastectomy