Liver Transplant and Active Ulcerative Colitis: A Case Report.

Abstract

BACKGROUND:

The association between ulcerative colitis (UC) and primary sclerosing cholangitis has been described for several years and can be classified as having a distinct disease phenotype from inflammatory bowel diseases (IBD). The simultaneous occurrence of decompensated liver disease requiring liver transplant and active IBD is a management challenge, considering that these patients may be at increased risk of infections, thromboembolic events, bleeding, and drug hepatotoxicity.

CASE PRESENTATION:

We describe a case of a 37-year-old patient with UC and sclerosing cholangitis presenting with severe decompensated rectocolitis complicated with thromboembolic phenomena and severe liver dysfunction who underwent liver transplant while using biological therapy to control bowel disease.

CONCLUSIONS:

This case highlights the evolution of sclerosing cholangitis to liver transplant in patients with decompensated UC. Despite the risk of recurrence, primary sclerosing cholangitis has excellent results after liver transplant. Despite the use of immunosuppression after liver transplant, biological therapy may be necessary to control IBD.

• Authors: Natália de Carvalho Trevizoli, Evelyn Jacome Obeid, Silas Gustavo Barboza Romeres, Carolina Augusta Matos de Oliveira, Henrique Carvalho Rocha, Daniela Mariano Carvalho-Louro, Gustavo de Sousa Arantes Ferreira, Priscila Brizolla De Campos, Raquel Francine Bundchen Ullmann, Ana Virgínia Ferreira Figueira, Luiz Gustavo Guedes Diaz, Fernando Marcus Felippe Jorge, Gabriel Oliveira Nunes Caja, Zuleica Barrio Bortoli, André Luis Conde Watanabe
• Journal: Transplantation proceedings (Transplant Proc) Vol. 54 Issue 5 Pg. 1361-1364 (Jun 2022) ISSN: 1873-2623 [Electronic] United States
• PMID: 35753819 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Topics

• Cholangitis, Sclerosing (complications, surgery)
• Colitis, Ulcerative (complications, surgery)
• Humans
• Inflammatory Bowel Diseases (complications)
• Liver Diseases (complications)
• Liver Transplantation (adverse effects)