The interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms.

Abstract

The Hippo signaling pathway was found coordinately modulates cell regeneration and organ size. Its dysregulation contributes to uncontrolled cell proliferation and malignant transformation. YAP/TAZ are two critical effectors of the Hippo pathway and have been demonstrated essential for the initiation or growth of most tumors. Noncoding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, have been shown to play critical roles in the development of many cancers. In the past few decades, a growing number of studies have revealed that ncRNAs can directly or indirectly regulate YAP/TAZ signaling. YAP/TAZ also regulate ncRNAs expression in return. This review summarizes the interactions between YAP/TAZ signaling and noncoding RNAs together with their biological functions on cancer progression. We also try to describe the complex feedback loop existing between these components.

• Authors: Yirao Zhang, Yang Wang, Hao Ji, Jie Ding, Keming Wang
• Journal: Journal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res) Vol. 41 Issue 1 Pg. 202 (Jun 14 2022) ISSN: 1756-9966 [Electronic] England
• PMID: 35701841 (Publication Type: Journal Article, Review)
• Copyright: © 2022. The Author(s).

Chemical References

• Adaptor Proteins, Signal Transducing
• MicroRNAs
• Transcription Factors
• YAP-Signaling Proteins

Topics

• Adaptor Proteins, Signal Transducing (genetics, metabolism)
• Humans
• MicroRNAs (genetics)
• Neoplasms (genetics)
• Transcription Factors (genetics, metabolism)
• YAP-Signaling Proteins