A Multifunctional Vanadium-Iron-Oxide Nanoparticle Eradicates Hepatocellular Carcinoma via Targeting Tumor and Endothelial Cells.

Abstract

Nanoparticles are widely used in biological research and cancer therapy. In hepatocellular carcinoma, several nanoplatforms have been synthesized and studied to improve the drug efficacy; however, these nanoplatforms are still insufficient to eradicate tumors. Herein, we have synthesized a novel vanadium (V)-iron-oxide (ION) nanoparticle (VIO) that combines chemodynamic, photothermal, and diagnostic capacities to enhance the tumor suppression effect in one agent with multiple functions. In the in vitro models, hepatocellular carcinoma cells are significantly inhibited by VIO-based nanoagents. The mechanistic study validates that VIO increases reactive oxygen species (ROS), which led to apoptosis and ferroptosis resulting in cell death. To our surprise, VIO targets not only tumor cells but also endothelial cells. In addition to inducing cell death, VIO also blocks tube formation and cell migration in human umbilical vein endothelial cell (HUVEC) and C166 models, indicating an antiangiogenic potential. In mouse tumor models, VIO retards tumor growth and induces apoptosis in tumor tissues. Furthermore, a significant blood vessel regression is seen in VIO-treated groups accompanied with larger necrotic areas. More interestingly, the activation of photothermal therapy completely eradicates tumor tissues. Taken together, this VIO nanoplatform could be a powerful anticancer candidate for nanodrug development.

• Authors: Xiaoming Yang, Jianmin Xiao, Lingyu Jiang, Lang Ran, Yangyang Fan, Minghui Zhang, Yuxue Xu, Cuifang Yao, Baijiao An, Yang Yang, Chunhua Yang, Geng Tian, Guilong Zhang, Yin Zhang
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 14 Issue 25 Pg. 28514-28526 (Jun 29 2022) ISSN: 1944-8252 [Electronic] United States
• PMID: 35698257 (Publication Type: Journal Article)

Chemical References

• Oxides
• Vanadium
• Iron

Topics

• Animals
• Carcinoma, Hepatocellular (drug therapy, metabolism)
• Cell Line, Tumor
• Human Umbilical Vein Endothelial Cells (metabolism)
• Humans
• Iron (pharmacology)
• Liver Neoplasms (drug therapy, metabolism)
• Mice
• Nanoparticles
• Oxides (pharmacology)
• Vanadium