Abstract | PURPOSE: METHODS: We recruited 1311 pregnant women at high risk for diabetes from the Obstetrics Clinic of Daxing District People's Hospital between June 2017 and December 2019. The tests performed during the first trimester included fasting blood glucose (FPG), HbA1c, and 75-g oral glucose tolerance test (OGTT) with 1hPG and 2hPG. Seventy-three pregnant women diagnosed with pregestational diabetes mellitus (PGDM) early in pregnancy and 36 who were missed in the second trimester were excluded. A total of 1202 women were followed up until 24-28 weeks for GDM. The receiver operating characteristic (ROC) and area under the ROC curve (AUC) were calculated to determine the predictive values of FPG, 1hPG, 2hPG, and HbA1c for GDM in early pregnancy in high-risk pregnant women. RESULTS: The AUC for 1hPG for the prediction of GDM in high-risk pregnant women was greater than those for FPG, 2hPG, and HbA1c. All differences were significant. The AUCs for the predictive values of FPG, 1hPG, 2hPG, and HbA1c in high-risk pregnant women were 0.63, 0.76, 0.71, and 0.67, respectively. The prevalence of PGDM among pregnant women at high risk of diabetes was 5.6%. CONCLUSION: First-trimester levels of FPG, 1hPG, 2hPG, and HbA1c in high-risk women are significant predictors of GDM, with 1hPG having the most significant predictive value.
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Authors | Xiaoxiao Peng, Mingyi Liu, Jun Gang, Ying Wang, Xiuhua Ma |
Journal | Archives of gynecology and obstetrics
(Arch Gynecol Obstet)
Vol. 307
Issue 5
Pg. 1451-1457
(05 2023)
ISSN: 1432-0711 [Electronic] Germany |
PMID | 35670847
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Chemical References |
- Blood Glucose
- Glycated Hemoglobin
|
Topics |
- Humans
- Female
- Pregnancy
- Adult
- Diabetes, Gestational
(diagnosis)
- Blood Glucose
- Glycated Hemoglobin
(metabolism)
- Glucose Tolerance Test
(methods)
- Pregnancy Trimester, First
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