Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia.

Abstract

Immunoglobulin (Ig) G4-positive cells are rarely observed in the lungs of patients with idiopathic interstitial pneumonias (IIPs). IgG1 may be more pathogenic than IgG4, with IgG4 having both pathogenic and protective roles in IgG4-related disease (IgG4-RD). However, the role of both IgG1 and IgG4 in IIPs remains unclear. We hypothesized that patients with IgG4-positive interstitial pneumonia manifest different clinical characteristics than patients with IgG4-RD. Herein, we identified the correlation of the degree of infiltration of IgG1- and IgG4-positive cells with IIP prognosis, using a Japanese nationwide cloud-based database. We included eighty-eight patients diagnosed with IIPs after multidisciplinary discussion, from April 2009 to March 2014. IgG4-positive cell infiltration was identified in 12/88 patients with IIPs and 8/41 patients with idiopathic pulmonary fibrosis (IPF). Additionally, 31/88 patients with IIPs and 19/41 patients with IPF were diagnosed as having IgG1-positive cell infiltration. IgG4-positive IIPs tended to have a better prognosis. Conversely, overall survival in cases with IgG1-positive IPF was significantly worse. IIPs were prevalent with IgG1- or IgG4-positive cell infiltration. IgG1-positive cell infiltration in IPF significantly correlated with a worse prognosis. Overall, evaluating the degree of IgG1-positive cell infiltration may be prognostically useful in cases of IPF.

• Authors: Masamichi Komatsu, Hiroshi Yamamoto, Takeshi Uehara, Yukihiro Kobayashi, Hironao Hozumi, Tomoyuki Fujisawa, Atsushi Miyamoto, Tomoo Kishaba, Fumihito Kunishima, Masaki Okamoto, Hideya Kitamura, Tae Iwasawa, Shoichiro Matsushita, Yasuhiro Terasaki, Shinobu Kunugi, Atsuhito Ushiki, Masanori Yasuo, Takafumi Suda, Masayuki Hanaoka
• Journal: Scientific reports (Sci Rep) Vol. 12 Issue 1 Pg. 9303 (06 03 2022) ISSN: 2045-2322 [Electronic] England
• PMID: 35661786 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022. The Author(s).

Chemical References

• Immunoglobulin G

Topics

• Humans
• Idiopathic Interstitial Pneumonias (pathology)
• Idiopathic Pulmonary Fibrosis (pathology)
• Immunoglobulin G
• Immunoglobulin G4-Related Disease (pathology)
• Lung (pathology)
• Prognosis
• Retrospective Studies