Evaluation of application protocol of the 4% hydrogen peroxide for at-home bleaching: A randomized clinical trial.

Abstract

OBJECTIVE:

Few studies evaluated low concentrations of hydrogen peroxide protocols. The aim of this paper was evaluated two application protocols using 4% hydrogen peroxide in at-home bleaching.

MATERIALS AND METHODS:

Eighty-six patients with upper canines' shade A2 or darker were randomly allocated under two experimental conditions: two daily applications of 1 h each or a 2-h single application. Color change was evaluated using Vita Classical, Vita Bleachedguide, and digital spectrophotometer weekly and 1 month after the bleaching procedure through one-way ANOVA. The risk and intensity of tooth sensitivity (TS) was assessed through visual and numeric rating scale and measured by Fisher's exact test, Mann-Whitney test and one-way ANOVA respectively.

RESULTS:

After 3 weeks, the mean difference for the ΔSGU Vita Classical (1.0; 95% CI -0.1 to 2.0), ΔEab (0.7; 95% CI -1.4 to 2.8), ΔE00 (0.1; 95% CI -1.4 to 1.6) and Wi (1.8; 95% CI -1.9 to 5.5) presented no difference (p > 0.08). The relative risk for TS was 0.91 (0.72 to 1.14) without significant difference neither in the risk (p = 0.6) nor in the TS intensity for both pain scales (p > 0.65).

CONCLUSIONS:

The application protocols evaluated (two daily applications of 1 h each or a 2-h single application) for at-home bleaching with 4% hydrogen peroxide did not showed differences in color change and tooth sensitivity.

CLINICAL RELEVANCE:

Higher amount of active hydrogen peroxide in two daily applications for at-home bleaching neither accelerate bleaching nor increase the risk or intensity of tooth sensibility.

• Authors: Alexandra M de Paula, Taíse Alessandra Hanzen, Heloísa Forville de Andrade, Eduardo Grokoski, Alessandro D Loguercio, Alessandra Reis
• Journal: Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] (J Esthet Restor Dent) Vol. 35 Issue 2 Pg. 360-367 (03 2023) ISSN: 1708-8240 [Electronic] England
• PMID: 35652434 (Publication Type: Clinical Trial Protocol, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 Wiley Periodicals LLC.

Chemical References

• Hydrogen Peroxide
• Tooth Bleaching Agents

Topics

• Humans
• Hydrogen Peroxide
• Tooth Bleaching (methods)
• Tooth Bleaching Agents
• Dentin Sensitivity
• Treatment Outcome
• Randomized Controlled Trials as Topic