A lncRNA signature associated with tumor immune heterogeneity predicts distant metastasis in locoregionally advanced nasopharyngeal carcinoma.
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| Abstract |
Increasing evidence has revealed the roles of long noncoding RNAs (lncRNAs) as tumor biomarkers. Here, we introduce an immune-associated nine-lncRNA signature for predicting distant metastasis in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). The nine lncRNAs are identified through microarray profiling, followed by RT-qPCR validation and selection using a machine learning method in the training cohort (n = 177). This nine-lncRNA signature classifies patients into high and low risk groups, which have significantly different distant metastasis-free survival. Validations in the Guangzhou internal (n = 177) and Guilin external (n = 150) cohorts yield similar results, confirming that the signature is an independent risk factor for distant metastasis and outperforms anatomy-based metrics in identifying patients with high metastatic risk. Integrative analyses show that this nine-lncRNA signature correlates with immune activity and lymphocyte infiltration, which is validated by digital pathology. Our results suggest that the immune-associated nine-lncRNA signature can serve as a promising biomarker for metastasis prediction in LA-NPC.
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| Authors | Ye-Lin Liang, Yuan Zhang, Xi-Rong Tan, Han Qiao, Song-Ran Liu, Ling-Long Tang, Yan-Ping Mao, Lei Chen, Wen-Fei Li, Guan-Qun Zhou, Yin Zhao, Jun-Yan Li, Qian Li, Sheng-Yan Huang, Sha Gong, Zi-Qi Zheng, Zhi-Xuan Li, Ying Sun, Wei Jiang, Jun Ma, Ying-Qin Li, Na Liu |
| Journal | Nature communications (Nat Commun) Vol. 13 Issue 1 Pg. 2996 (05 30 2022) ISSN: 2041-1723 [Electronic] England |
| PMID | 35637194 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © 2022. The Author(s). |
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