Abstract | BACKGROUND: METHODS: We completed a multi-center case-control study in Jiangxi Province, China. Neuroimaging examination was done in all cases. Controls were stroke-free adults recruited from the community in the case concentration area and matched with the cases in 1:1 ratio by age and sex. Odds ratios (OR) were calculated by conditional logistic regression. RESULTS: We enrolled 11,729 case-control pairs. The estimated ORs among patients with 1, 2 and 3 metabolic diseases were 3.16 (2.78-3.60), 7.11 (6.16-8.20), 12.22 (9.73-15.36), respectively after adjusting age, body mass index, urban-rural areas, cardiac disease, smoking, alcohol intake, physically active, high intake of salt, meat-biased diet, high homocysteine. The coexistence of HTN and DM (OR: 7.67), the coexistence of HTN and DLP (OR:7.58), and the coexistence of DM and DLP (OR:3.64) can all significantly increase the risk of stroke. HTN alone or combined other metabolic diseases were significantly more strongly associated with intracerebral haemorrhage than ischemic stroke. CONCLUSIONS:
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Authors | Yuhang Wu, Huilie Zheng, Songbo Hu, Xiaoyun Chen, Yiying Chen, Jie Liu, Yan Xu, Xiaona Chen, Liping Zhu, Wei Yan |
Journal | The International journal of neuroscience
(Int J Neurosci)
Vol. 133
Issue 9
Pg. 1055-1063
(Dec 2023)
ISSN: 1563-5279 [Electronic] England |
PMID | 35635805
(Publication Type: Journal Article)
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Topics |
- Adult
- Humans
- Risk Factors
- Case-Control Studies
- Comorbidity
- Stroke
(epidemiology, complications)
- Hypertension
(epidemiology, complications)
- Diabetes Mellitus
(epidemiology)
- Metabolic Diseases
(epidemiology, complications)
- China
(epidemiology)
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