Colon cancer is one of the most common gastrointestinal
tumors in the world. Currently, the commonly used methods such as
radiotherapy,
chemotherapy and drug treatments are often ineffective and have significant side effects. Here we developed a safe and efficient
biomaterials based anti-
tumor nanoplatform (M@NPs/miR365), which was formed with poly (
citrate-
peptide) (PCP), miRNA365 mimic and MC38
cancer cell membrane (M). PCP could efficiently deliver miR365 mimic into MC38
cancer cells, promote the apoptosis of MC38
tumor cells and regulate the expression of Bcl2 and Ki67 in vitro.
Tumor cell membranes were prepared by a fast and convenient sonication method. This
tumor cell membrane-coated drug delivery system M@NPs can effectively reduce macrophage uptake and increase the stability of NPs. And the MC38
tumor model mice experiment showed that M@NPs/miR365 via caudal vein injection effectively inhibit
tumor development. Based on the immune escape and homologous targeting of
cancer cells and efficient gene transfection ability of NPs, this "Trojan horse" like "Pseudotumor cell" carries the target gene miR365 mimic to the
tumor site and realizes
cancer therapy. Noteworthy, the drug delivery system has good biocompatibility. Thus, this safe drug delivery strategy mediated by
cancer cell membrane and gene therapy may have a certain significance for reducing the gap between nanoplatform and
tumor clinical treatment.