Abstract | INTRODUCTION AND HYPOTHESIS: METHODS: A systematic review and meta-analysis was carried out women with and without pelvic organ prolapse. This meta-analysis was conducted on research articles describing the evaluation of collagen type-1 expression between patients with and without POP. The articles were obtained from PubMed, EBSCO, and ProQuest, and were published between January 2000 and June 2021. Pooled mean difference (MD) and pooled odds ratio (OR) were calculated using fixed effect models. Review Manager (RevMan 5.4) was used to analyze the data. The main outcome measures were pooled MD and pooled OR of collagen type-1 expression in patients with and without POP. RESULTS: A total of seven case-control studies were included in the meta-analysis using the effect size of the MD and two case-control studies were included in the meta-analysis using the effect size of the OR. A total of 247 POP cases and 132 non-POP cases were identified from the studies. Our study indicated that patients with POP had a lower level of collagen type-1 expression than non-POP patients (MD = -6.77; 95% CI: -8.37, -5.17, p < 0.00001). Patients with low expression of collagen type-1 in pelvic support tissue are at a more than 3 times higher risk of suffering from pelvic organ prolapse (OR = 3.23, 95% CI: 1.52 to 6.87, p = 0.002). CONCLUSION:
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Authors | Akbar Novan Dwi Saputra, Dicky Moch Rizal, Sarrah Ayuandari, Nuring Pangastuti |
Journal | International urogynecology journal
(Int Urogynecol J)
Vol. 33
Issue 7
Pg. 1803-1812
(07 2022)
ISSN: 1433-3023 [Electronic] England |
PMID | 35596801
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | © 2022. The International Urogynecological Association. |
Chemical References |
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Topics |
- Collagen Type I
(biosynthesis, metabolism)
- Female
- Humans
- Pelvic Organ Prolapse
(metabolism)
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