Macrophage membrane biomimetic drug delivery system: for inflammation targeted therapy.

Abstract

In recent years, there have been many exciting developments in the biomedical applications of the macrophage membrane bionic drug delivery system (MM-Bio-DDS). Macrophages, as an important immune cell, are involved in initiating and regulating the specific immune response of the body. Therefore, the inflammatory process related to macrophages is an important goal in the diagnosis and treatment of many diseases. In this review, we first summarise the different methods of preparation, characterisation, release profiles and natural advantages of using macrophages as a drug delivery system (DDS). Second, we introduce the processes of various chronic inflammatory diseases and the role of macrophages in them, specifically clarifying how the MM-Bio-DDS provides a wide and effective treatment for the targeted inflammatory site. Finally, based on the existing research, we propose the application prospect and existing challenges of the MM-Bio-DDS, especially the problems in clinical transformation, to provide new ideas for the development and utilisation of the MM-Bio-DDS in targeted drug delivery for inflammation and the treatment of diseases.

• Authors: Yulu Zhang, Yu Long, Jinyan Wan, Songyu Liu, Ai Shi, Dan Li, Shuang Yu, Xiaoqiu Li, Jing Wen, Jie Deng, Yin Ma, Nan Li
• Journal: Journal of drug targeting (J Drug Target) Vol. 31 Issue 3 Pg. 229-242 (03 2023) ISSN: 1029-2330 [Electronic] England
• PMID: 35587560 (Publication Type: Review, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Humans
• Biomimetics
• Drug Delivery Systems
• Macrophages
• Inflammation (drug therapy)
• Treatment Outcome
• Nanoparticles