Clinical outcome of photodynamic therapy for the treatment of cervical intraepithelial neoplasia grade 2.

Abstract

Five-aminolaevulinic acid photodynamic therapy (ALA-PDT) was used to treat 79 cervical intraepithelial neoplasia 2 (CIN 2) patients who desired preservation of fertility ,between Oct 2018 and Dec 2020. Three months after treatment, among the 65 patients who returned for follow-up, full recovery and improvement rates were 43/65 and 16/65, respectively, resulting in a total response rate of 90.77%. This suggests that ALA-PDT is worthy of clinical application, even as monotherapy. The result of immune testing also indicated significant promotion of CD4+T expression during the recovery process, highlighting the importance of immune responses in different prognoses.

• Authors: Huihui Cai, Yanci Che, Xin Sun, Xiao Yu, Fengsheng Yu, Feng Hou, Yankui Wang, Tingting Ma
• Journal: Photodiagnosis and photodynamic therapy (Photodiagnosis Photodyn Ther) Vol. 39 Pg. 102906 (Sep 2022) ISSN: 1873-1597 [Electronic] Netherlands
• PMID: 35577063 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Chemical References

• Photosensitizing Agents
• Aminolevulinic Acid

Topics

• Aminolevulinic Acid (therapeutic use)
• Female
• Humans
• Papillomavirus Infections (drug therapy)
• Photochemotherapy (methods)
• Photosensitizing Agents (therapeutic use)
• Uterine Cervical Neoplasms (drug therapy)
• Uterine Cervical Dysplasia (drug therapy)