The role of platelet glycoprotein IIb / IIIa inhibitors in current treatment of acute coronary syndrome.

Abstract

Current management of patients with acute coronary syndrome (ACS) includes a dual antiplatelet therapy with acetylsalicylic acid and a platelet P2Y12 receptor inhibitor. For patients without a high risk of bleeding, prasugrel and ticagrelor are preferred, since their effect is more pronounced, less dependent on metabolism of a specific patient, and occurs faster that the effect of clopidogrel. The prescription rate of platelet glycoprotein IIb/IIIa (GP IIb / IIIa) receptor inhibitors has considerably decreased. However, these drugs remain relevant in percutaneous coronary interventions in patients with a high risk of coronary thrombosis or a massive coronary thrombus, in thrombotic complications of the procedure, and in the "no-reflow" phenomenon. The intravenous route of GP IIb / IIIa inhibitor administration provides their effectiveness in patients with difficulties of drug intake or with impaired absorption of oral medications. This review presents clinical and pharmacological characteristics of various GP IIb / IIIa inhibitors and data of randomized clinical studies and registries of recent years that evaluated results of their use in patients with ACS.

• Authors: T S Sukhinina, D V Pevzner, A V Mazurov, T N Vlasik, N G Solovieva, N S Kostritca, R M Shakhnovich, I S Yavelov
• Journal: Kardiologiia (Kardiologiia) Vol. 62 Issue 4 Pg. 64-72 (Apr 30 2022) ISSN: 0022-9040 [Print] Russia (Federation)
• PMID: 35569165 (Publication Type: Journal Article, Review)

Chemical References

• Platelet Aggregation Inhibitors
• Platelet Glycoprotein GPIIb-IIIa Complex
• Platelet Membrane Glycoprotein IIb
• Ticlopidine

Topics

• Acute Coronary Syndrome (therapy)
• Humans
• Platelet Aggregation Inhibitors (adverse effects)
• Platelet Glycoprotein GPIIb-IIIa Complex (metabolism, therapeutic use)
• Platelet Membrane Glycoprotein IIb (therapeutic use)
• Ticlopidine (pharmacology)