Th1/Th2/Th17 Cytokine Profile among Different Stages of COVID-19 Infection.

Abstract

Aim:

To characterize Th1/Th2/Th17 cytokine profile (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ, and IL-17A) among different stages of COVID-19 infection.

Methods:

This was a cross-sectional study which included six healthy individuals and 68 patients who were admitted with COVID-19 in the Department of Medicine, at All India Institute of Medical Sciences, New Delhi, from July 2020 to September 2020. Patients were categorized into mild, moderate, and severe COVID-19 groups, and serum samples were drawn for the measurement of Th1/Th2/Th17 cytokines (IL-4, IL-6, IL-10, TNF-α, IFN-γ, and IL-17A) which was done by BD™ Cytometric Bead Array.

Results:

All the cytokines showed dynamic expression in the COVID-19 group, of which only IL-6 was statistically significant. Among the three severity groups of COVID-19, increased severity did not transform into increased cytokine level, with the exception for IL-6, which was statistically significant.

Conclusions:

In our small sample study, six cytokines expressions were evaluated however most of them were elevated in COVID-19 patients but were not statistically significant except IL-6.

• Authors: Gaurav Gupta, Imtiyaz Shareef, Shalini Tomar, Mylathal Sivasamy Naveen Kumar, Shivam Pandey, Radhika Sarda, Ravinder Singh, Bimal Kumar Das, Sanjeev Sinha
• Journal: National Academy science letters. National Academy of Sciences, India (Natl Acad Sci Lett) Vol. 45 Issue 4 Pg. 363-369 ( 2022) ISSN: 0250-541X [Print] India
• PMID: 35528283 (Publication Type: News)
• Copyright: © The Author(s), under exclusive licence to The National Academy of Sciences, India 2022.