Abstract | BACKGROUND: METHODS AND RESULTS: We enrolled 40 healthy control subjects (group I) and 146 EH patients (group II). Plasma FGF23 concentration was measured in all subjects. In this study, FGF23 level was significantly higher in group II (660.77 [446.26, 1,001.72]) pg/mL compared with the controls (73.23 [52.92, 103.69]) pg/mL (p < 0.001). Logistic regression analysis revealed that FGF23 was independently correlated to LVH and LA enlargement. Receiver operating characteristic (ROC) curve indicated FGF23 had an optimal cutoff of 834.63 pg/mL for LVH (area under ROC curve [AUC], 0.913; 95% CI: 0.863-0.963) and 497.06 pg/mL for LA enlargement (AUC, 0.694; 95% CI: 0.612-0.768). The DeLong test was performed to compare AUCs of FGF23 and BNP, and the AUC of FGF23 (0.913) was statistically higher compared to AUC of BNP (0.661) (DeLong test: p < 0.001) in the diagnosis of LVH. CONCLUSION: Plasma FGF23 level elevated in EH, increased with the progress of cardiac remodeling, and was independently related to LVH and LA enlargement. The diagnostic value of FGF23 in cardiac remodeling, especially for LVH, was superior to BNP.
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Authors | Jiayu Han, Xiaoyang Yuan, Wei Song, Yunpeng Cheng, Yan Lu, Ying Zhang, Yan Liu, Yinong Jiang |
Journal | Cardiology
(Cardiology)
Vol. 147
Issue 3
Pg. 271-280
( 2022)
ISSN: 1421-9751 [Electronic] Switzerland |
PMID | 35500559
(Publication Type: Journal Article)
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Copyright | © 2022 S. Karger AG, Basel. |
Chemical References |
- FGF23 protein, human
- Natriuretic Peptide, Brain
- Fibroblast Growth Factors
- Fibroblast Growth Factor-23
|
Topics |
- Essential Hypertension
- Fibroblast Growth Factor-23
(blood)
- Fibroblast Growth Factors
- Humans
- Hypertrophy, Left Ventricular
- Kidney
(physiology)
- Natriuretic Peptide, Brain
- Ventricular Remodeling
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