[Perioperative management of laparoscopic cholecystectomy in a patient with paroxysmal nocturnal haemoglobinuria undergoing ravulizumab treatment].

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by hemolysis, thrombosis, and bone marrow failure. Infection, pregnancy, and surgical operation have the potential to evoke severe episodes of hemolysis and thrombosis. Therefore, the use of an antibody agent against complement component 5 (C5), eculizumab, one day before the operation is recommended. Ravulizumab is a newly approved long-acting antibody agent against C5. Thus, little is known about perioperative management with ravulizumab. We experienced a 43-year-old female patient who safely underwent laparoscopic cholecystectomy under ravulizumab treatment for PNH. Ravulizumab was administered one day before the operation. Laparoscopic cholecystectomy for cholelithiasis was performed under intravenous anesthesia, intermittent air compression of the lower extremities, and low pneumoperitoneum pressure. Additionally, heparin was administered, and the patient left the sickbed early without significant postoperative complications. Like eculizumab, complement inhibition by ravulizumab is also considered effective in the perioperative management of patients with PNH. However, close cooperation with surgeons and anesthesiologists and careful management based on clinical symptoms and laboratory data such as LDH, CH50, and D-dimer are essential.

• Authors: Moyu Kimura, Yu Nishiyama, Hiroki Ueda, Akiko Kitajo, Tomoyuki Arimatsu, Mai Kuboki, Atsushi Takahata, Makiko Saito, Chizuko Sakashita, Keigo Okada, Yoshihiro Umezawa, Toshikage Nagao, Masahide Yamamoto, Shuji Tohda, Minoru Tanabe, Takehiko Mori, Ayako Nogami
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 63 Issue 4 Pg. 260-264 ( 2022) ISSN: 0485-1439 [Print] Japan
• PMID: 35491214 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal, Humanized
• ravulizumab

Topics

• Adult
• Antibodies, Monoclonal, Humanized
• Cholecystectomy, Laparoscopic (adverse effects)
• Female
• Hemoglobinuria, Paroxysmal (complications, drug therapy)
• Hemolysis
• Humans
• Pregnancy
• Thrombosis (etiology)