Released
oxygen plays a critical role in reducing destructive
tumor behavior. This study aims to utilize decomposed
hydrogen peroxide as an
oxygen source by conjugating it with
polyvinylpyrrolidone (PVP). PVP-
hydrogen peroxide complex (PHP) composed of different ratios of (PVP : H2O2) (0.5 : 1, 1 : 1, 1 : 1.5, 1 : 5, and 1 : 10) were successfully synthesized. PHP complex with a ratio of 1 : 1.5 was chosen as the optimized ratio, and it was incorporated into the
polymethyl methacrylate (
PMMA) nanofibrous scaffold via the electrospinning technique. Results have revealed that the
PMMA-10% PHP complex provided a significant morphological structure of nanofibrous scaffolds. The mechanical properties of
PMMA-10% PHP nanofibers showed the most suitable mechanical features such as Young's modulus, elongation-at-break (%), and maximum strength, in addition to the highest degree of swelling. All PHP complex scaffolds released
oxygen in a sustained manner. However, the
PMMA-10% PHP complex gave the highest concentration of released-
oxygen with (∼8.9 mg L-1, after 2.5 h).
PMMA-10% PHP nanofibers provided an ideal model for released-
oxygen scaffold with anti-
cancer effect and high selectivity for
cancer cells, especially for
breast cancer cells. Nanofibrous scaffolds with different composition revealed high cell viability for normal cells. Such outcomes support the suitability of using synthesized nanofibrous scaffolds as released-
oxygen biomaterials to enhance
cancer cells' sensitivity and maximize the treatment effect.