Potential efficacy of hepatic arterial infusion chemotherapy using gemcitabine, cisplatin, and 5-fluorouracil for intrahepatic cholangiocarcinoma.

Abstract

Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis, as the resectability rate is low due to its diagnosis at a late/advanced stage. Moreover, most patients with resected ICC eventually relapse. Hepatic arterial infusion chemotherapy (HAIC) has been indicated only by a few reports to be effective in patients with advanced ICC; thus, its efficacy for these patients remains unclear. This study aimed to evaluate the efficacy of HAIC using gemcitabine, cisplatin, and 5-fluorouracil in patients with advanced ICC. A total of 18 patients who underwent HAIC were retrospectively investigated. The patients received gemcitabine, cisplatin, and 5-fluorouracil through one artery. In patients who received gemcitabine plus cisplatin (n = 10), the response and disease control rates were 0% and 80.0%, respectively; the median overall survival (OS) and progression-free survival (PFS) after treatment initiation were 6.3 and 3.7 months, respectively. In patients who never received chemotherapy (n = 8), the response and disease control rates were 37.5% and 75%, respectively; the median OS and PFS were 20.6 and 8.1 months, respectively. Moreover, we compared the patients who received HAIC using gemcitabine, cisplatin, and 5-fluorouracil to patients whose tumors were refractory to systemic gemcitabine and cisplatin therapy. The OS of the patients who received HAIC was better than that of the patients who received standard chemotherapy cohort since the gemcitabine plus cisplatin combination therapy-refractory response and disease onset (P = 0.045, 0.006). HAIC using gemcitabine, cisplatin, and 5-fluorouracil may be effective as a therapeutic option for patients with advanced ICC.

• Authors: Masatsugu Ishii, Osamu Itano, Jun Morinaga, Hirofumi Shirakawa, Satoshi Itano
• Journal: PloS one (PLoS One) Vol. 17 Issue 4 Pg. e0266707 ( 2022) ISSN: 1932-6203 [Electronic] United States
• PMID: 35452492 (Publication Type: Journal Article)

Chemical References

• Deoxycytidine
• Cisplatin
• Fluorouracil
• Gemcitabine

Topics

• Antineoplastic Combined Chemotherapy Protocols
• Bile Duct Neoplasms (drug therapy, pathology)
• Bile Ducts, Intrahepatic (pathology)
• Cholangiocarcinoma (drug therapy, pathology)
• Cisplatin
• Deoxycytidine (analogs & derivatives)
• Fluorouracil
• Humans
• Infusions, Intra-Arterial
• Liver Neoplasms (pathology)
• Neoplasm Recurrence, Local (pathology)
• Retrospective Studies
• Treatment Outcome
• Gemcitabine