Interaction of curcumin with glioblastoma cells via high and low linear energy transfer radiation therapy inducing radiosensitization effects.

Abstract

Glioblastoma is a deadly cancer tumor in the brain and has a survival rate of about 15 months. Despite the high mortality rate, temozolomide has proven to increase the survival rate of patients when combined with radiotherapy. However, its effects may be limited because some patients develop therapeutic resistance. Curcumin has proven to be a cancer treatment due to its broad anticancer spectrum, high efficiency and low toxic level. Additionally, curcumin significantly enhanced radiation efficacy under high and low Linear Energy Transfer (LET) radiation conditions in vitro. In combination with radiation, curcumin increased the cell population in the sub-G1 phase and the reactive oxygen species (ROS) level, ultimately increasing GBM cellular apoptosis. The radiosensitizing effects of curcumin are much higher in neutron (high LET)-irradiated cell lines than in γ (low LET)-irradiated cell lines. Curcumin plus neutron combination significantly inhibited cell invasion compared with that of single treatment or curcumin combined γ-ray treatment. Curcumin enhances the radiosensitivity of Glioblastoma (GBM), suggesting it may have clinical utility in combination cancer treatment with neutron high-LET radiation.

• Authors: Jeong-Yub Kim, Chan-Woong Jung, Won Seok Lee, Hee-Jin Kim, Hyeon-Jeong Jeong, Myung-Jin Park, Won Il Jang, Eun Ho Kim
• Journal: Journal of radiation research (J Radiat Res) Vol. 63 Issue 3 Pg. 342-353 (May 18 2022) ISSN: 1349-9157 [Electronic] England
• PMID: 35446963 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Curcumin

Topics

• Apoptosis
• Cell Line, Tumor
• Curcumin (pharmacology)
• Glioblastoma (pathology)
• Humans
• Linear Energy Transfer
• Radiation Tolerance