[Analysis of Chemotherapy-Induced Nausea and Vomiting during Chemotherapy for Gastric Cancer].

Abstract

BACKGROUND:

Chemotherapy-induced nausea and vomiting(CINV)are typical side effects caused by chemotherapy. We analyzed CINV during first-line chemotherapy for gastric cancer.

MATERIALS AND METHOD:

Thirty-one patients who received first-line chemotherapy for gastric cancer were retrospectively assessed for CINV.

RESULTS:

The median age was 70 years, and the gender(male/female)was 23/8 cases. NK1 receptor antagonist, 5-HT3 receptor antagonist, and dexamethasone were used as antiemetic agents in 29 patients(94%). Sixteen patients(52%)had Grade 1 or higher nausea, and 6 patients (19%)had Grade 1 or higher vomiting, and complete control of nausea and vomiting was achieved in 21 patients(68%). Nausea was significantly more frequent in patients with liver metastasis(p=0.0008), but there was no significant difference in vomiting(p=1.0000). There was no significant difference in the occurrence of CINV between chemotherapy regimens or combination of olanzapine.

CONCLUSION:

During first-line chemotherapy for gastric cancer, 3 antiemetic agents were used in 94% of cases, and the complete control rate of CINV was 67.8%.

• Authors: Junji Kawada, Manatsu Mizuno, Akio Fukada, Masaya Nakano, Masatoshi Murotani, Shinnosuke Nagano, Naoki Yoneda, Shinya Kidogami, Yukako Mokutani, Tomoya Kishimoto, Yasuji Hashimoto, Hajime Hirose, Shinichi Yoshioka, Shigeyuki Tamura, Yo Sasaki
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 49 Issue 4 Pg. 462-464 (Apr 2022) ISSN: 0385-0684 [Print] Japan
• PMID: 35444136 (Publication Type: Journal Article)

Chemical References

• Antiemetics
• Antineoplastic Agents

Topics

• Aged
• Antiemetics (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Female
• Humans
• Male
• Nausea (chemically induced, drug therapy, prevention & control)
• Retrospective Studies
• Stomach Neoplasms (drug therapy)
• Vomiting (chemically induced, drug therapy, prevention & control)