Abstract |
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as shaping cancer immunosurveillance and response to immunotherapy. Our understanding of the complex relationship between different host-intrinsic microorganisms, as well as the multifaceted mechanisms by which they influence health and disease, has grown tremendously-hastening development of novel therapeutic strategies that target the microbiota to improve treatment outcomes in cancer. Accordingly, the evaluation of a patient's microbial composition and function and its subsequent targeted modulation represent key elements of future multidisciplinary and precision-medicine approaches. In this Review, we outline the current state of research toward harnessing the microbiome to better prevent and treat cancer.
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Authors | Elizabeth M Park, Manoj Chelvanambi, Neal Bhutiani, Guido Kroemer, Laurence Zitvogel, Jennifer A Wargo |
Journal | Nature medicine
(Nat Med)
Vol. 28
Issue 4
Pg. 690-703
(04 2022)
ISSN: 1546-170X [Electronic] United States |
PMID | 35440726
(Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | © 2022. Springer Nature America, Inc. |
Topics |
- Gastrointestinal Microbiome
(physiology)
- Humans
- Immunotherapy
- Microbiota
- Neoplasms
(pathology, therapy)
- Precision Medicine
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