Abstract | OBJECTIVE: This study aimed to verify the presence of polymorphism rs2165241 of the lysyl oxidase-like 1 (Loxl1) gene and its association with pelvic organ prolapse (POP) in Brazilian women and determine risk factors for POP development. METHODS: The study was previously approved by the local research and ethics board. Postmenopausal women were included and divided into POP (stages III and IV) and control (stages 0 and I) groups. Peripheral blood samples were collected, and the DNA sequence of interest was analyzed by real-time reverse-transcriptase polymerase chain reaction. We used logistic regression and considered a recessive model of inheritance for the analysis, with p < 0.05 for significance. RESULTS: A total of 836 women were assessed: 426 POP cases and 410 controls. The frequencies of CC, CT and TT genotypes were similar in both groups. Age (odds ratio [OR] = 1.1, 95% confidence interval [CI] = 1.07; 1.14), number of vaginal births (OR = 17.06, 95% CI = 5.94; 48.97), family history (OR = 2.87, 95% CI = 1.57; 5.22) and weight of largest newborn (OR = 1.001, 95% CI = 1.0003; 1.001) were independent risk factors for POP, while multiple cesarean sections (two or more) was protective (OR = 0.17, 95% CI = 0.07; 0.42). CONCLUSION: No association was detected between rs2165241 of the Loxl1 gene and POP.
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Authors | C L Costa E Silva, M A T Bortolini, N C Batista, R S P Silva, J B Teixeira, É Oliveira, R P Souto, R A Castro |
Journal | Climacteric : the journal of the International Menopause Society
(Climacteric)
Vol. 25
Issue 4
Pg. 407-412
(08 2022)
ISSN: 1473-0804 [Electronic] England |
PMID | 35440244
(Publication Type: Journal Article)
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Chemical References |
- Amino Acid Oxidoreductases
- LOXL1 protein, human
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Topics |
- Amino Acid Oxidoreductases
(genetics)
- Female
- Humans
- Infant, Newborn
- Pelvic Organ Prolapse
(genetics)
- Polymorphism, Genetic
- Postmenopause
(genetics)
- Pregnancy
- Vagina
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