The critical role of short-chain fatty acids in health and disease: A subtle focus on cardiovascular disease-NLRP3 inflammasome-angiogenesis axis.

Abstract

Short-chain fatty acids (SCFAs), metabolites of intestinal microorganisms, have been linked to the occurrence and development of a variety of disorders, including cardiovascular disease (CVD), which is frequently accompanied by a sustaining inflammatory response and aberrant angiogenesis. Accumulating evidence from the study emphasizes that SCFAs are closely connected with the activation of the NLRP3 inflammasome (NACHT, LRR, and PYD domains-containing protein 3) and the process of angiogenesis. This review summarizes emerging literature on the impact of SCFAs on various physiological processes, with a subtle attention on the interaction between SCFAs and CVD (especially atherosclerosis, myocardial infarction, and hypertension), SCFAs and NLRP3 inflammasome, as well as SCFAs and angiogenesis. As a result, we speculate that it is convincing that SCFAs play a mediating role in the microbiota-inflammasome-angiogenesis-CVD axis, opening up a new horizon to investigate the function or level of SCFAs as a therapeutic strategy for CVD.

• Authors: Juan Yao, Yu Chen, Ming Xu
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 238 Pg. 109013 (05 2022) ISSN: 1521-7035 [Electronic] United States
• PMID: 35436628 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Chemical References

• Fatty Acids, Volatile
• Inflammasomes
• NLR Family, Pyrin Domain-Containing 3 Protein

Topics

• Cardiovascular Diseases
• Fatty Acids, Volatile (metabolism)
• Humans
• Inflammasomes (metabolism)
• Intestines
• NLR Family, Pyrin Domain-Containing 3 Protein (metabolism)