REIA: A database for cancer A-to-I RNA editing with interactive analysis.

Abstract

Epitranscriptomic changes caused by adenosine-to-inosine (A-to-I) RNA editing contribute to the pathogenesis of human cancers; however, only a small fraction of the millions editing sites detected so far has clear functionality. To facilitate more in-depth studies on the editing, this paper offers REIA (http://bioinfo-sysu.com/reia), an interactive web server that analyses and visualizes the association between human cancers and A-to-I RNA editing sites (RESs). As a comprehensive database, REIA curates not only 8,447,588 RESs from 9,895 patients across 34 cancers, where 33 are from TCGA and 1 from GEO, but also 13 different types of multi-omic data for the cancers. As an interactive server, REIA provides various options for the user to specify the interested sites, to browse their annotation/editing level/profile in cancer, and to compare the difference in multi-omic features between editing and non-editing groups. From the editing profiles, REIA further detects 658 peptides that are supported by mass spectrum data but not yet covered in any prior works.

• Authors: Huimin Zhu, Lu Huang, Songbin Liu, Zhiming Dai, Zhou Songyang, Zhihui Weng, Yuanyan Xiong
• Journal: International journal of biological sciences (Int J Biol Sci) Vol. 18 Issue 6 Pg. 2472-2483 ( 2022) ISSN: 1449-2288 [Electronic] Australia
• PMID: 35414795 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The author(s).

Chemical References

• Inosine
• RNA
• Adenosine

Topics

• Adenosine (genetics, metabolism)
• Humans
• Inosine (genetics, metabolism)
• Neoplasms (genetics)
• RNA
• RNA Editing (genetics)