Fulminant Respiratory Failure Caused by Anti-asparaginyl tRNA Synthetase (Anti-KS) Antibody Syndrome-related Interstitial Lung Disease.

Abstract

Anti-asparaginyl transfer RNA (tRNA) synthetase (KS) antibodies, detected in <5% patients with anti-aminoacyl-tRNA synthetase antibody syndrome, are strongly associated with interstitial pneumonia but not myositis and skin symptoms. A recent report suggested that most patients with interstitial pneumonia and anti-KS antibody (KS-ILD) may present with chronic disease. We herein report a rare case of severe acute respiratory failure in a KS-ILD patient requiring extracorporeal membrane oxygenation (ECMO). ECMO is useful for facilitating not only lung rest until recovery but also the definitive diagnosis and treatment of ILD. KS-ILD can develop acutely with fulminant respiratory failure, as observed in this case.

• Authors: Naohiro Oda, Akihiko Taniguchi, Toshiyuki Aokage, Satoru Senoo, Kenta Nagashima, Reo Mitani, Ichiro Takata, Nobuaki Miyahara
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 61 Issue 22 Pg. 3409-3414 (Nov 15 2022) ISSN: 1349-7235 [Electronic] Japan
• PMID: 35370234 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Amino Acyl-tRNA Synthetases

Topics

• Humans
• Autoantibodies
• Lung Diseases, Interstitial (complications, diagnosis)
• Amino Acyl-tRNA Synthetases
• Myositis (diagnosis)
• Respiratory Insufficiency (etiology, therapy)