Catechol modification of non-woven chitosan gauze for enhanced hemostatic efficacy.

Abstract

Development of efficient hemostatic gauze is critical to increasing survival rate by quick bleeding control of life-threatening hemorrhage. Herein, a novel chitosan non-woven hemostatic gauze is made by slightly surface modification with a special catechol compound, i.e. 3-(9,11,13-pentadecatrienyl)-1,2-benzenediol with a long side hydrophobic alkyl chain. Its wettability, interaction with red blood cell and platelet, and hemostatic efficacy on rat injuries are evaluated. This chitosan-catechol gauze demonstrates impressive hemostatic performances on rat femoral artery and liver laceration injury models (blood loss of this modified chitosan gauze is less than 17% of that of pristine chitosan gauze). Additionally, it is biodegradable, and maintains non-cytotoxicity. It integrates three structure and function effects together, i.e., anchoring effect between catechol and tissue, blood repelling effect from hydrophobic alkyl chain, and blood wicking effect from hydrophilic chitosan. Therefore, a new hemostatic mechanism is proposed for the excellent hemostatic potentials of this chitosan gauze.

• Authors: Huaying He, Caixia Sun, Yunxiang Weng, Hongjian Huang, Peng Ni, Yan Fang, Renfeng Xu, Zhengchao Wang, Haiqing Liu
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 286 Pg. 119319 (Jun 15 2022) ISSN: 1879-1344 [Electronic] England
• PMID: 35337522 (Publication Type: Journal Article)
• Copyright: Copyright © 2022. Published by Elsevier Ltd.

Chemical References

• Catechols
• Hemostatics
• Chitosan
• catechol

Topics

• Animals
• Bandages
• Catechols
• Chitosan (chemistry)
• Hemostatics (pharmacology, therapeutic use)
• Rats