Polysomnography-guided mandibular distraction osteogenesis in Pierre Robin sequence patients.

Abstract

STUDY OBJECTIVES:

Craniofacial malformations with micrognathia cause high grades of obstructive sleep apnea (OSA) measured by polysomnography (PSG). Mandibular distraction osteogenesis is a novel procedure for upper airway obstruction relief. Our primary objective was to describe the utilization of PSGs to improve obstruction in patients undergoing mandibular distraction.

METHODS:

This is a retrospective study. Patients with micrognathia and severe upper airway obstruction, presenting with severe OSA diagnosed by PSG, were included from a single tertiary care center between 2015 and 2019. PSGs were done (1) prior to surgery, (2) once the cosmetic goal was achieved (Post-Op 1), and (3) if residual moderate-to-severe OSA was seen, every 2 nights until mild or no OSA was achieved (Post-Op 2).

RESULTS:

Thirteen patients were included. The median age at surgery was 1.1 months (10 days-3 months). All 13 patients had baseline severe OSA, with a median obstructive apnea-hypopnea index of 33 events/h and a median O2 nadir of 73%. Post-Op 1 PSG was done at a median of 6 days after surgery. Median first postoperative obstructive apnea-hypopnea index in all 13 patients was 6.8 events/h, with a median O2 nadir of 87%. A median additional distraction of 3 mm was needed beyond the traditionally recommended advancement. Long-term follow-up studies at or after 1 year were done in 5 patients, all showing persistent nonsevere OSA.

CONCLUSIONS:

This is the first case series utilizing PSGs as a guide for mandibular distraction osteogenesis in patients with micrognathia showing the need for jaw overcorrection to achieve resolution of OSA.

CITATION:

Kochhar R, Modi V, de Silva N, et al. Polysomnography-guided mandibular distraction osteogenesis in Pierre Robin sequence patients. J Clin Sleep Med. 2022;18(7):1749-1755.

• Authors: Rashi Kochhar, Vikash Modi, Neranjan de Silva, Seyni Gueye-Ndiaye, Jay M Neugarten, Mary J Ward, Linda M Gerber, Anjile An, Elizabeth Mauer, Haviva Veler
• Journal: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine (J Clin Sleep Med) Vol. 18 Issue 7 Pg. 1749-1755 (07 01 2022) ISSN: 1550-9397 [Electronic] United States
• PMID: 35332870 (Publication Type: Journal Article)
• Copyright: © 2022 American Academy of Sleep Medicine.

Topics

• Airway Obstruction (etiology, surgery)
• Humans
• Infant
• Mandible (surgery)
• Micrognathism (complications, surgery)
• Osteogenesis, Distraction (adverse effects, methods)
• Pierre Robin Syndrome (complications, surgery)
• Polysomnography
• Retrospective Studies
• Sleep Apnea, Obstructive (complications)
• Treatment Outcome