The susceptibility of Cryptococcus neoformans to an antimycotic agent (G2) from alfalfa.

Abstract

Compound G2, 2-beta-hydroxy-3-beta-O-(beta-D-glucopyranosyl)-delta 12-oleanene-23,28-dionic acid, isolated from alfalfa roots, demonstrated considerable activity against Cryptococcus neoformans (MIC value of 2 micrograms/ml). Compound G2 exhibited rapid killing of this fungus (MFC value of 4 micrograms/ml) suggesting that it might be a useful active agent in the treatment of cryptococcosis.

• Authors: I Polacheck, U Zehavi, M Naim, M Levy, R Evron
• Journal: Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology (Zentralbl Bakteriol Mikrobiol Hyg A) Vol. 261 Issue 4 Pg. 481-6 (Jul 1986) ISSN: 0176-6724 [Print] Germany
• PMID: 3532631 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Plant Extracts
• Saponins
• Triterpenes
• medicagenic acid-3-O-glucopyranoside

Topics

• Antifungal Agents (pharmacology)
• Cryptococcus (drug effects)
• Cryptococcus neoformans (drug effects)
• Kinetics
• Medicago sativa
• Plant Extracts (pharmacology)
• Saponins (pharmacology)
• Triterpenes (pharmacology)