Post-vaccination SARS-cov-2 infection in nursing home residents, Bordeaux, France.

Abstract

OBJECTIVE:

To describe COVID-19 breakthrough infections in two nursing homes (NHs) sites of active COVID-19 clusters despite optimal vaccination coverage.

METHODS:

A cross-sectional study was conducted in two NHs of south-western France, following the investigation of COVID-19 clusters (February-March 2021). SARS-CoV-2-confirmed infection was defined by positive RT-PCR. Antibodies neutralization capacities were tested in a subgroup of fully-vaccinated and seropositive-residents.

RESULTS:

Of the 152 residents, 66% were female with median age 87 years (IQR: 80.0-90.2). Overall, 132 (87%) residents received 2 doses of vaccine, 14 (9%) one dose and 6 (4%) were unvaccinated. Forty-seven (31%) residents had confirmed infection (45 (98%) with variant 20I/501Y.V1). All 6 non-vaccinated residents, 4 /14 who had one dose and 37/132 that had two doses, were infected. Of the 39 residents reporting symptoms, 12 and 3 presented severe and critical disease, respectively. One resident with a confirmed infection died. Infected-residents had a median anti-S IgG titre of 19 116.0 (IQR: 3 028.0-39 681.8 AU/mL), 19 times higher than that of non-infected vaccinated persons (1,207.0; IQR: 494.0-2,782.0). In the subgroup of 19 residents tested for neutralizing antibodies, the neutralizing titre (50%) was strongly positively correlated with the anti-S IgG titre (correlation coefficient = 0.83), and 1.5 times higher for the infected than non-infected residents [5.9 (IQR: 5.3-6.9) vs. 3.6 (2.9-3.8)].

CONCLUSION:

Institutionalized elderly persons who undergo breakthrough infection develop higher titres of anti-S IgGs, which are strongly correlated with the neutralizing capacity of the antibodies. These results advocate for additional vaccine doses in this population.

• Authors: Marion Lartigau, Eric Ouattara, Camille Tumiotto, Harald Wodrich, Laurent Busson, Pascale Trimoulet, Elise Thiel, Mahissata Nouzille, Maria Dubos, Marie-Edith Lafon, Véronique Gilleron, Patrick Dehail, Nathalie Salles, Denis Malvy
• Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (J Clin Virol) Vol. 149 Pg. 105134 (04 2022) ISSN: 1873-5967 [Electronic] Netherlands
• PMID: 35313222 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Chemical References

• COVID-19 Vaccines
• Immunoglobulin G
• Vaccines

Topics

• Aged
• Aged, 80 and over
• COVID-19 (prevention & control)
• COVID-19 Vaccines
• Cross-Sectional Studies
• Female
• France (epidemiology)
• Humans
• Immunoglobulin G
• Male
• Nursing Homes
• SARS-CoV-2
• Vaccination
• Vaccines