Abstract | BACKGROUND: MATERIAL AND METHODS: A retrospective cohort analysis was performed using the United States Renal Data System, a medical claims database of all ESRD patients undergoing dialysis in the US. Logistic regression analysis was used to investigate the association of psoriasis with pneumonia in ESRD patients. RESULTS: A total of 6841 (0.7%) ESRD patients were diagnosed with psoriasis; 385,976 (36%) ESRD patients had pneumonia. Although simple models showed that psoriasis was associated with an increased risk of pneumonia in the ESRD population (odds ratio (OR) = 1.14), the final multivariable model found that psoriasis was protective for pneumonia (OR = 0.56) when controlling for age, race, sex, ethnicity, dialysis modality, Charlson Comorbidity Index (CCI), multiple sclerosis, tobacco use and alcohol use. This is due to both the CCI and tobacco use being strong confounders of the association of psoriasis and pneumonia. Black, other race and Hispanic ethnicity were also protective for pneumonia, while increasing age and CCI, female sex, hemodialysis, multiple sclerosis and tobacco and alcohol use were associated with increased risk. CONCLUSIONS: When controlling for multiple factors, psoriasis does not increase the risk for pneumonia in ESRD patients. In this cohort, other factors, such as the CCI and tobacco use, were more strongly associated with increased risk for pneumonia than psoriasis.
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Authors | Lorry Aitkens, Jennifer L Waller, Stephanie L Baer, Azeem Mohammed, Sarah Tran, Budder Siddiqui, Sandeep Padala, Lufei Young, Mufaddal Kheda, Wendy B Bollag |
Journal | The American journal of the medical sciences
(Am J Med Sci)
Vol. 364
Issue 1
Pg. 29-35
(07 2022)
ISSN: 1538-2990 [Electronic] United States |
PMID | 35289277
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
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Copyright | Published by Elsevier Inc. |
Topics |
- Female
- Humans
- Kidney Failure, Chronic
(diagnosis, epidemiology, therapy)
- Multiple Sclerosis
- Pneumonia
(complications, epidemiology)
- Psoriasis
(complications, epidemiology)
- Renal Dialysis
(adverse effects)
- Retrospective Studies
- Risk Factors
- United States
(epidemiology)
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