Change in Cardiovascular Health Metrics and Risk for Proteinuria Development: Analysis of a Nationwide Population-Based Database.

Abstract

INTRODUCTION:

Evidence is lacking regarding the association between cardiovascular health (CVH) metrics and the risk for proteinuria.

METHODS:

We performed this observational cohort study including 865,087 participants (median age, 46 years, 60.7% men) with negative proteinuria at the initial health check-up, who underwent repeated health check-ups within 4 years. Ideal CVH metrics included nonsmoking, body mass index <25 kg/m2, physical activity at goal, eating breakfast, blood pressure <120/80 mm Hg, fasting plasma glucose <100 mg/dL, and total cholesterol <200 mg/dL. The primary outcome was incident proteinuria, defined as ≥1 + on the urine dipstick test.

RESULTS:

Participants were categorized as having low CVH metrics defined as having 0-2 ideal CVH metrics (n = 84,439), middle CVH metrics defined as having 3-4 ideal CVH metrics (n = 335,773), and high CVH metrics defined as having 5-7 ideal CVH metrics (n = 444,875). Compared with low CVH metrics, middle CVH metrics (odds ratio (OR): 0.61, 95% CI: 0.59-0.63) and high CVH metrics (OR: 0.45, 95% CI: 0.43-0.46) were associated with a lower risk of proteinuria. The OR of a one-point increase in the ideal number of CVH metrics was 0.83 (95% CI: 0.82-0.83). All CVH metrics components except for ideal total cholesterol were associated with a decreased risk of proteinuria. A one-point improvement in the number of ideal CVH metrics at 1 year after the initial health check-up was associated with a decreased incidence of proteinuria (OR: 0.90, 95% CI: 0.89-0.92).

CONCLUSION:

Not only maintaining better CVH metrics but also improving CVH metrics would prevent developing proteinuria in a general population.

• Authors: Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Hidetaka Itoh, Kojiro Morita, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Satoko Yamaguchi, Kentaro Kamiya, Atsuhiko Matsunaga, Junya Ako, Akira Fukui, Akira Nishiyama, Takashi Yokoo, Koichi Node, Toshimasa Yamauchi, Masaomi Nangaku, Hideo Yasunaga, Issei Komuro
• Journal: American journal of nephrology (Am J Nephrol) Vol. 53 Issue 2-3 Pg. 240-248 ( 2022) ISSN: 1421-9670 [Electronic] Switzerland
• PMID: 35259741 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 The Author(s). Published by S. Karger AG, Basel.

Topics

• Blood Pressure
• Cardiovascular Diseases (epidemiology, etiology, prevention & control)
• Cardiovascular System
• Female
• Health Status
• Humans
• Male
• Middle Aged
• Proteinuria (epidemiology)
• Quality Indicators, Health Care
• Risk Factors