Genetic Lipid Disorders Associated with Atherosclerotic Cardiovascular Disease: Molecular Basis to Clinical Diagnosis and Epidemiologic Burden.

Abstract

Genetic lipid disorders, ranging from common dyslipidemias such as familial hypercholesterolemia, lipoprotein (a), and familial combined hyperlipidemia to rare disorders including familial chylomicronemia syndrome and inherited hypoalphalipoproteinemias (ie, Tangier and fish eye diseases), affect millions of individuals in the United States and tens of millions around the world and are often undiagnosed in the general population. Clinicians should take into consideration the potential of inherited lipid disorders or syndromes when severe derangements in lipid parameters are observed. Patients' combined genotype and phenotype should be evaluated in conjunction with a host of environmental factors impacting their risk of atherosclerotic cardiovascular disease.

• Authors: Reed Mszar, Gayley B Webb, Vivek T Kulkarni, Zahid Ahmad, Daniel Soffer
• Journal: The Medical clinics of North America (Med Clin North Am) Vol. 106 Issue 2 Pg. 325-348 (Mar 2022) ISSN: 1557-9859 [Electronic] United States
• PMID: 35227434 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Lipids

Topics

• Atherosclerosis (diagnosis, epidemiology, genetics)
• Cardiovascular Diseases (complications)
• Dyslipidemias (epidemiology, genetics)
• Humans
• Hyperlipoproteinemia Type I (complications)
• Lipids
• Risk Factors
• United States (epidemiology)