Non-ischemic cerebral enhancing lesions after thrombectomy: a multicentric retrospective French national registry.

Abstract

To report the occurrence of non-ischemic cerebral enhancing (NICE) lesions following mechanical thrombectomy (MT) through the retrospective French nationwide registry of NICE lesions. All thrombectomy capable stroke centers (TSC) in France were invited to fill out a questionnaire disseminated through a trainee-led research network (JENI-RC: Jeunes en Neuroradiologie Interventionnelle-Research Collaborative). NICE lesions were defined according to previous literature as delayed onset punctate, nodular, or annular foci enhancements with peri-lesion edema and vascular distribution in the territory of the MT with no other confounding disease. All 43 TSC French centers responded. Three patients were reported by 3 different centers over a total of 34,824 MT (2015-2020). Patient no. 1 developed symptomatic NICE lesions 8 weeks after MT with combination of aspiration and stentriever for a right middle cerebral artery occlusion. Patient no. 2 developed asymptomatic NICE lesions 5 weeks after MT with direct thromboaspiration for a right middle cerebral artery occlusion. Patient no. 3 developed symptomatic NICE lesions 6 weeks after MT with direct thromboaspiration, and combination of aspiration and stentriever for a basilar artery occlusion. This study provides evidence that NICE lesions following MT are a possible rare complication with a similar presentation as previously described following endovascular aneurysm treatment. Both radiologists and neurologists should be aware of this adverse event and make use of MRI contrast agents in case of unexplained symptoms/images during follow-up after MT.

• Authors: Géraud Forestier, Simon Escalard, Jacques Sedat, Suzana Saleme, Charbel Mounayer, Alexis Montcuquet, Stanislas Smajda, Marie Cantier, Charles Gregoire, Karolina Hankiewicz, Yves Chau, Laurent Suissa, Jérôme Berge, Frédéric Clarençon, Aymeric Rouchaud, Eimad Shotar, JENI Research collaboration
• Journal: Neuroradiology (Neuroradiology) Vol. 64 Issue 5 Pg. 1037-1042 (May 2022) ISSN: 1432-1920 [Electronic] Germany
• PMID: 35199209 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Topics

• Aortic Aneurysm, Abdominal
• Blood Vessel Prosthesis Implantation
• Brain Ischemia (diagnostic imaging, surgery)
• Endovascular Procedures (adverse effects)
• Humans
• Infarction, Middle Cerebral Artery
• Registries
• Retrospective Studies
• Stroke (diagnostic imaging, surgery)
• Thrombectomy (methods)
• Treatment Outcome