Abstract | BACKGROUND: METHODS: RESULTS: A total of 844 patients (age 65 ± 10 years, 77% men) were included. Of the overall population, 145 (17%) patients were in group 1, 161 (19%) in group 2, 157 (19%) in group 3 and 381 (45%) in group 4. After a median follow-up of 95 (51-145) months, 517 (61%) patients died. Patients in groups 2, 3 and 4 had significantly higher mortality rates than those in group 1 (p = 0.025, p < 0.001 and p < 0.001, respectively). On multivariable analysis, groups 3 (HR 1.415; 95% CI 1.024-1.957; p = 0.032) and 4 (HR 1.599; 95% CI 1.204-2.123; p = 0.001) were independently associated with all-cause mortality. CONCLUSIONS: Most CRT candidates already present with extensive cardiac remodeling at the time of referral. Detection of the extent of cardiac remodeling before CRT implantation results in improved risk-stratification, and underscores the need for early referral.
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Authors | Jan Stassen, Mand Khidir, Xavier Galloo, Kensuke Hirasawa, Juhani Knuuti, Nina Ajmone Marsan, Victoria Delgado, Pieter van der Bijl, Jeroen J Bax |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 355
Pg. 65-71
(05 15 2022)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 35189167
(Publication Type: Journal Article)
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Copyright | Copyright © 2022. Published by Elsevier B.V. |
Topics |
- Aged
- Cardiac Resynchronization Therapy
(methods)
- Female
- Heart Failure
(complications, diagnosis, therapy)
- Humans
- Male
- Middle Aged
- Prognosis
- Treatment Outcome
- Ventricular Remodeling
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