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Cardiac Resynchronization Therapy

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The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.

Also Known As:

Atrio-Biventricular Pacing; Biventricular Pacing; Cardiac Resynchronization; Cardiac Resynchronization Pacing Therapy; Resynchronization Pacing Therapy, Cardiac; Atrio Biventricular Pacing; Pacing, Atrio-Biventricular; Pacing, Biventricular; Resynchronization Therapy, Cardiac; Resynchronization, Cardiac; Therapy, Cardiac Resynchronization

Networked: 2961 relevant articles (362 outcomes, 468 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 15318
- Electric Stimulation Therapy: 463
  - Artificial Cardiac Pacing: 14
    - Cardiac Resynchronization Therapy: 2961

Experts

1.	Bax, Jeroen J: 87 articles (01/2016 - 08/2002)
2.	Schalij, Martin J: 77 articles (10/2015 - 08/2002)
3.	Moss, Arthur J: 68 articles (12/2015 - 05/2008)
4.	Zareba, Wojciech: 60 articles (12/2015 - 01/2008)
5.	McNitt, Scott: 59 articles (09/2015 - 10/2010)
6.	Abraham, William T: 52 articles (01/2016 - 06/2002)
7.	Linde, Cecilia: 47 articles (01/2016 - 07/2002)
8.	Gasparini, Maurizio: 45 articles (12/2015 - 01/2003)
9.	Auricchio, Angelo: 45 articles (01/2015 - 01/2002)
10.	Goldenberg, Ilan: 44 articles (12/2015 - 05/2008)

Related Diseases

1.	Heart Failure 11/15/2014 - "In conclusion, cardiac resynchronization therapy in combination with an implantable cardioverter-defibrillator resulted in improved survival among Medicare patients meeting class I criteria and most patients meeting class IIa criteria as outlined in the current guidelines for device-based therapy in heart failure, although the effect sizes were lower than those demonstrated in recent trials." 07/01/2011 - "Cardiac resynchronization therapy (CRT) has dramatically improved the symptoms and prognosis of patients with heart failure in large randomized clinical trials. " 06/01/2010 - "The most recent MADIT-CRT trial showed that a cardiac resynchronization therapy device with defibrillator (CRT-D) was effective in reducing the risk of heart failure or death, whichever came first, in cardiac patients who were asymptomatic or minimally symptomatic (New York Heart Association class I or II) with reduced ejection fraction < or =0.30 and wide QRS complex > or =130 ms when compared with an implantable cardiac defibrillator (ICD) device. " 04/01/2014 - "Although cardiac resynchronization therapy (CRT) is effective in most patients with heart failure (HF) and ventricular dyssynchrony, a significant minority of patients (approximately 30%) are non-responders. " 07/01/2012 - "Some chronic heart failure (CHF) patients show remarkable improvement in left ventricular (LV) remodeling after cardiac resynchronization therapy (CRT), for unclear reasons. "
2.	Bundle-Branch Block (Fascicular Block) 10/01/2007 - "Cardiac resynchronization therapy is effective in patients with a low ejection fraction and left bundle branch block, but 20%-30% do not respond despite selection of the optimal site for pacing on the left ventricle. " 02/01/2012 - "Studies in canine hearts with acute left bundle branch block (LBBB) showed that endocardial left ventricular (LV) pacing improves the efficacy of cardiac resynchronization therapy (CRT) compared with conventional epicardial LV pacing. " 07/01/2015 - "Cardiac resynchronization therapy (CRT) has been shown to improve left ventricular (LV) function and exercise performance in patients with left bundle branch block. " 12/01/2012 - "If confirmed in prospective studies, our results may help to predict the prognosis of patients with left bundle branch block and different degrees of interVD and intraVD, particularly those subjects undergoing cardiac resynchronization therapy." 01/01/2008 - "The indications and efficacy of cardiac resynchronization therapy (CRT) have not been sufficiently clarified in patients with right bundle branch block (RBBB). "
3.	Mitral Valve Insufficiency (Mitral Regurgitation) 06/01/2006 - "Atrioventricular (AV) interval optimization, ensuring the best filling and the abolishment of presystolic mitral regurgitation, is crucial for the efficacy of cardiac resynchronization therapy (CRT). " 03/01/2014 - "Compared with standard biventricular pacing, the final optimized pacing configuration improved global intraventricular synchrony (decreasing LPEI from 158 ± 36 ms to 134 ± 29 ms; P<0.001), LV systolic efficiency (decreasing LPEI/LV ejection time from 0.58 ± 0.18 to 0.46 ± 0.13; P<0.001) and LV filling (increasing LV filling time/RR from 44 ± 8% to 47 ± 7%; P<0.001) and decreased mitral valve regurgitation. " 10/19/2004 - "We tested the hypothesis that an immediate reduction in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT) results from improved coordinated timing of the papillary muscle insertion sites, using the novel approach of mechanical activation strain mapping. " 03/01/2008 - "The aim of the current study was to evaluate the relationship between the presence of left ventricular (LV) dyssynchrony at baseline and acute vs. late improvement in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT). " 11/20/2007 - "The purpose of this study was to evaluate the relationship between dyssynchrony involving the mitral valve apparatus and the acute improvement in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT). "
4.	Systolic Heart Failure 03/04/2009 - "Cardiac resynchronization therapy by a biventricular pacemaker or defibrillator is recommended for treating selected patients with systolic heart failure who are in NYHA class III or IV despite optimal medical therapy, have a left ventricular ejection fraction of < or = 35%, and a QRS width of > or = 120 ms. Improvement in symptoms or ventricular remodelling is observed in 50-80% of patients. " 09/01/2009 - "Cardiac resynchronization therapy (CRT) is a novel treatment for systolic heart failure and in successful cases reverse remodeling occurs with reduction of left ventricular (LV) dimensions and volumes. " 09/01/2009 - "More recently, ICD therapy also has been shown to be effective for the primary prevention of SCD in patients with systolic heart failure, sometimes with the addition of cardiac resynchronization therapy. " 08/01/2008 - "Biventricular pacing has been shown to improve the overall clinical outcomes in patients with systolic heart failure and ventricular conduction delay on electrocardiogram. " 01/01/2012 - "Cardiac resynchronization therapy (CRT) is effective in reducing morbidity and mortality in systolic heart failure patients with cardiac dyssynchrony as demonstrated in studies with primarily Western populations. "
5.	Atrial Fibrillation 11/01/2005 - "For patients undergoing AV node ablation for atrial fibrillation, biventricular pacing provides a significant improvement in the 6-minute hallway walk test and ejection fraction compared to right ventricular pacing. " 12/01/2013 - "The purpose of this study is to determine whether, in patients with atrial fibrillation (AF) undergoing cardiac resynchronization therapy (CRT), atrioventricular junction ablation (AVJA) is associated with a better outcome than treatment with rate-slowing drugs. " 10/01/2011 - "On the basis of the current knowledge, cardiac resynchronization therapy (CRT) cannot be recommended as a first-line treatment for patients with severely symptomatic permanent atrial fibrillation undergoing atrioventricular (AV) junction ablation. " 10/01/2013 - "Remarkably little evidence exists that cardiac resynchronization therapy (CRT) is effective in patients who have atrial fibrillation (AF) but who otherwise seem suitable for this treatment. " 12/01/2000 - "The MUSTIC trial suggested that cardiac resynchronisation using biventricular pacing improved patients symptomatically whether or not the patient was in atrial fibrillation. "

Related Drugs and Biologics

1.	Angiotensins
2.	Aldosterone
3.	Brain Natriuretic Peptide (Natrecor)
4.	pro-brain natriuretic peptide (1-76)
5.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
6.	Glucose (Dextrose)
7.	Vasopressins (Vasopressin)
8.	clopidogrel (Plavix)
9.	Paroxetine (Paxil)
10.	Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)

Related Therapies and Procedures

1.	Cardiac Resynchronization Therapy
2.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
3.	Defibrillators (Defibrillator)
4.	Drug Therapy (Chemotherapy)
5.	Thoracotomy