A Suggested Link Between Antithrombin Dose and Rate of Recovery from Disseminated Intravascular Coagulation in Patients with Severe Organ Failure.

Abstract

INTRODUCTION:

The efficacy of antithrombin (AT) supplementation against septic disseminated intravascular coagulation (DIC) may depend on various pre-existing factors, particularly the AT dose and multiple organ dysfunction severity. This study aimed to identify the impactful factors for early DIC recovery.

METHODS:

Patients' clinical records, including AT therapy and septic DIC data, were retrospectively extracted from January 2015 to December 2020. The patients were divided into those with early DIC recovery (n = 34) and those without (n = 37). Multivariate logistic regression analysis determined significant independent factors. Time-to-event analysis confirmed how these factors affected the DIC recovery time.

RESULTS:

The AT dose per patient body weight (odds ratio [95% confidence interval]: 2.879 [1.031-8.042], P = 0.044) and pre-existing organ dysfunction severity (0.333 [0.120-0.920], P = 0.034) were significant independent factors affecting early DIC recovery. A higher AT dose significantly shortened the DIC recovery time among patients with severe organ dysfunction (P < 0.01), but not among non-severe patients (P = 0.855).

CONCLUSION:

The therapeutic efficacy of AT treatment for septic DIC might depend on the severity of pre-existing organ failure and the AT dose per patient body weight.

• Authors: Hiromitsu Kuroda, Hiroomi Tatsumi, Tomoko Sonoda, Yoshiki Masuda
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) 2022 Jan-Dec Vol. 28 Pg. 10760296221080942 ISSN: 1938-2723 [Electronic] United States
• PMID: 35187966 (Publication Type: Journal Article)

Chemical References

• Antithrombins

Topics

• APACHE
• Age Factors
• Aged
• Aged, 80 and over
• Antithrombins (administration & dosage, adverse effects, therapeutic use)
• Body Weight
• Comorbidity
• Disseminated Intravascular Coagulation (drug therapy, epidemiology, etiology)
• Female
• Humans
• Logistic Models
• Male
• Middle Aged
• Multiple Organ Failure (epidemiology, etiology)
• Organ Dysfunction Scores
• Patient Acuity
• Retrospective Studies
• Sepsis (complications)
• Sex Factors