Karanahan, a
cancer treatment technology aimed at eradicating
tumor-initiating stem cells, has already proven effective in 7
tumor models. Karanahan comprises the following procedures: (1) collecting surgical specimens, (2) determining the duration of the DNA repair process in
tumor cells exposed to a cross-linking
cytostatic agent, and (3) determining the time point, when cells, including
tumor-initiating stem cells, are synchronized in the certain phase of the cell cycle after triple exposure to the
cytostatic, becoming vulnerable for the terminal treatment, which is supposed to completely eliminate the rest of survived
tumor-initiating stem cells. Determining these basic
tumor properties allows to design the schedule for the administration of a cross-linking
cytostatic and a complex composite
DNA preparation. Being conducted in accordance with the schedule designed, Karanahan results in the large-scale apoptosis of
tumor cells with elimination of
tumor-initiating stem cells.
METHODS: We report the first use of Karanahan in patients diagnosed with
breast cancer. Technical details of handling surgical specimens for determining the essential Karanahan parameters (
tumor volume, cell number, cell proliferation status, etc) have been worked out. The terminally ill patient, who was undergoing
palliative treatment and whose
tumor specimen matched the required criteria, received a complete course of Karanahan.
CONCLUSIONS: