Abstract | OBJECTIVE: METHODS: In this single-center retrospective study, the data of patients with unresectable HCC who had received TACE+AC or AC treatment during March 2017 to May 2021 were assessed. Patients in the AC group received intravenous administration of camrelizumab 200 mg every 3 weeks and oral apatinib 250 mg/day treatment. Patients in the TACE+AC group received the same dose of camrelizumab and apatinib 1 week after TACE. The primary endpoint of the study was overall survival (OS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs) as the secondary endpoints. RESULTS: A total of 108 patients were enrolled in the study. There were 52 patients in the AC group and 56 patients in TACE+AC group. Median OS was significantly longer in the TACE+AC group than in the AC group (24.8 vs. 13.1 months; P = 0.005). Patients in the TACE+AC group achieved a higher ORR [24 (42.9%) vs. 9 (17.3%), P = 0.004] than those in the AC group. Patients in the TACE+AC group also achieved a higher disease control rate (DCR) [48 (85.7%) vs. 30 (57.7%), P = 0.001] than patients in the AC group. There was no significant difference in the incidence of AEs related to apatinib and camrelizumab between the two groups, except for gastrointestinal reaction (P > 0.05, all; P < 0.05, gastrointestinal reaction). CONCLUSION:
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Authors | Shuguang Ju, Chen Zhou, Chongtu Yang, Chaoyang Wang, Jiacheng Liu, Yingliang Wang, Songjiang Huang, Tongqiang Li, Yang Chen, Yaowei Bai, Wei Yao, Bin Xiong |
Journal | Frontiers in oncology
(Front Oncol)
Vol. 11
Pg. 835889
( 2021)
ISSN: 2234-943X [Print] Switzerland |
PMID | 35174073
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 Ju, Zhou, Yang, Wang, Liu, Wang, Huang, Li, Chen, Bai, Yao and Xiong. |