Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides.

Abstract

Natural products are a major source of biologically active compounds that make promising lead molecules for developing efficacious drug-like molecules. Natural withanolides are found in many flora and fauna, including plants, algae, and corals, that traditionally have shown multiple health benefits and are known for their anti-cancer, anti-inflammatory, anti-bacterial, anti-leishmaniasis, and many other medicinal properties. Structures of these withanolides possess a few reactive sites that can be exploited to design and synthesize more potent and safe analogs. In this review, we discuss the literature evidence related to the medicinal implications, particularly anticancer properties of natural withanolides and their synthetic analogs, and provide perspectives on the translational potential of these promising compounds.

• Authors: Amandeep Singh, Asif Raza, Shantu Amin, Chendil Damodaran, Arun K Sharma
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 27 Issue 3 (Jan 28 2022) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 35164150 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• Antineoplastic Agents
• Withanolides

Topics

• Animals
• Anti-Inflammatory Agents (chemical synthesis, chemistry, pharmacology, therapeutic use)
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology, therapeutic use)
• Drug Design
• Drug Discovery
• Humans
• Neoplasms (drug therapy)
• Withanolides (chemical synthesis, chemistry, pharmacology, therapeutic use)