German S3 Evidence-Based Guidelines on Focal Therapy in Localized Prostate Cancer: The First Evidence-Based Guidelines on Focal Therapy.

Abstract

BACKGROUND:

Focal therapy (FT) is an option to treat localized prostate cancer (PCa) and preserve healthy prostate tissue in order to reduce known side effects from primary whole-gland treatment. The available FT modalities are manifold. Until now, national and international PCa guidelines have been cautious to propose recommendations regarding FT treatment since data from prospective controlled trials are lacking for most FT modalities. Moreover, none of the international guidelines provides a separate section on FT. In this purpose, we provide a synopsis of the consensus-based German S3 guidelines for a possible international use.

SUMMARY:

The recently published update of the German S3 guidelines, an evidence- and consensus-based guideline, provides a section on FT with recommendations for diagnostic work-up, indications, modalities, and follow-up. This section consists of 12 statements and recommendations for FT in the treatment of localized PCa.

KEY MESSAGE:

The German S3 guidelines on PCa are the first to incorporate recommendations for FT based on evidence and expert consensus including indication criteria for FT, pretreatment, and follow-up diagnostic pathways as well as an extended overview of FT techniques and the current supportive evidence.

• Authors: Angelika Borkowetz, Andreas Blana, Dirk Böhmer, Hannes Cash, Udo Ehrmann, Tobias Franiel, Thomas-Oliver Henkel, Stefan Höcht, Glen Kristiansen, Stefan Machtens, Peter Niehoff, Tobias Penzkofer, Michael Pinkawa, Jan Philipp Radtke, Wilfried Roth, Ullrich Witzsch, Roman Ganzer, Heinz Peter Schlemmer, Marc-Oliver Grimm, Oliver W Hakenberg, Martin Schostak
• Journal: Urologia internationalis (Urol Int) Vol. 106 Issue 5 Pg. 431-439 ( 2022) ISSN: 1423-0399 [Electronic] Switzerland
• PMID: 35144260 (Publication Type: Journal Article, Review)
• Copyright: © 2022 The Author(s). Published by S. Karger AG, Basel.

Topics

• Cryotherapy
• Humans
• Male
• Prospective Studies
• Prostatic Neoplasms (diagnosis, therapy)