The Role and Application of Exosomes in Gastric and Colorectal Cancer.

Abstract

Gastric cancer and colorectal cancer are malignant tumors found in the human gastrointestinal tract. Bidirectional communication between tumor cells and their microenvironment can be realized through the transmission of exosomes-small, cell-derived vesicles containing complex RNA and proteins. Exosomes play an important role in the proliferation, metastasis, immune response, and drug resistance of cancer cells. In this review, we focus on the role and application of exosomes in gastric and colorectal cancer. We also summarize the role of exosomes secreted by different types of cells in tumor development and as drug carriers in cancer treatment.

• Authors: Qirong Li, Dongxu Wang, Dayong Ding, Ye Feng, Ruizhi Hou, Dianfeng Liu, Chao Lin, Yongjian Gao
• Journal: Frontiers in pharmacology (Front Pharmacol) Vol. 12 Pg. 825475 ( 2021) ISSN: 1663-9812 [Print] Switzerland
• PMID: 35111071 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022 Li, Wang, Ding, Feng, Hou, Liu, Lin and Gao.