Effects of red blood cell transfusions given to non-septic critically ill patients: a propensity score matched study.

Abstract

INTRODUCTION:

Previous studies have demonstrated that low-grade red blood cell transfusions (RBC) given to septic patients are harmful. The objectives of the present study were to compare mortality and morbidity in non-septic critically ill patients who were given low-grade RBC transfusions at haemoglobin level > 70 γ L-1 with patients without RBC-transfusions any of the first 5 days in intensive care.

MATERIAL AND METHODS:

Adult patients admitted to a general intensive care unit between 2007 and 2018 at a university hospital were eligible for inclusion. Patients who received > 2 units RBC transfusion per day during the first 5 days after admisasion, with pre-transfusion haemoglobin level < 70 γ L-1 or with severe sepsis or septic shock, were excluded.

RESULTS:

In total, 9491 admissions were recorded during the study period. Propensity score matching resulted in 2 well matched groups with 674 unique patients in each. Median pre-transfusion haemoglobin was 98 γ L-1 (interquartile range 91-107 γ L-1). Mortality was higher in the RBC group with an absolute risk increase for death at 180 days of 5.9% (95% CI: 3.6-8.3; P < 0.001). Low-grade RBC-transfusion was also associated with renal, circulatory, and respiratory failure as well as a higher SOFA-max score. Sensitivity analyses suggested that disease trajectories during the exposure time did not significantly differ between the groups.

CONCLUSIONS:

Low-grade RBC-transfusions given to non-septic critically ill patients without significant anaemia were associated with increased mortality, increased kidney, circulatory, and respiratory failure, as well as higher SOFA-max score.

• Authors: Thomas Kander, Caroline U Nilsson, Daniel Larsson, Peter Bentzer
• Journal: Anaesthesiology intensive therapy (Anaesthesiol Intensive Ther) Vol. 53 Issue 5 Pg. 390-397 ( 2021) ISSN: 1731-2531 [Electronic] Poland
• PMID: 35100796 (Publication Type: Journal Article)

Topics

• Anemia (therapy)
• Critical Illness (therapy)
• Erythrocyte Transfusion (methods)
• Humans
• Propensity Score
• Prospective Studies