A Nanostructured Phthalocyanine/Albumin Supramolecular Assembly for Fluorescence Turn-On Imaging and Photodynamic Immunotherapy.

Abstract

Smart phototheranostic nanomaterials are of significant interest for high-quality imaging and targeted therapy in the precision medicine field. Herein, a nanoscale photosensitizer (NanoPcM) is constructed through the self-assembly of morpholine-substituted silicon phthalocyanine (PcM) and albumin. NanoPcM displays a turn-on fluorescence depending on the acid-induced abolition of the photoinduced electron transfer effect (change in molecular structure) and disassembly of the nanostructure (change in supramolecular structure), which enables low-background and tumor-targeted fluorescence imaging. In addition, its efficient type I photoreaction endows NanoPcM with a superior immunogenic photodynamic therapy (PDT) effect against solid tumors. The combination of NanoPcM-based PDT and αPD-1-based immunotherapy can efficiently inhibit tumor growth, reduce spontaneous lung metastasis, and trigger abscopal effects. This study should provide a perspective for the future design of nanomaterials as promising phototheranostics for cancer imaging and therapy.

• Authors: Rui Wang, Kyu-Hwan Kim, Jiyoon Yoo, Xingshu Li, Nahyun Kwon, Yun-Hui Jeon, Suk-Kyung Shin, Seung Seok Han, Dong-Sup Lee, Juyoung Yoon
• Journal: ACS nano (ACS Nano) Vol. 16 Issue 2 Pg. 3045-3058 (02 22 2022) ISSN: 1936-086X [Electronic] United States
• PMID: 35089696 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Albumins
• Isoindoles
• Photosensitizing Agents
• phthalocyanine

Topics

• Albumins
• Cell Line, Tumor
• Fluorescence
• Immunotherapy
• Isoindoles
• Nanostructures
• Photochemotherapy (methods)
• Photosensitizing Agents (chemistry, pharmacology, therapeutic use)