Multifunctional Probes with High Utilization Rates: Self-Assembled Merocyanine Nanoparticles in Water as Acid-Base Indicators and Mitochondrion-Targeting Chemotherapeutic Agents.

Abstract

Multifunctional probes with high utilization rates have great value in practical applications in various fields such as cancer diagnosis and therapy. Here we have synthesized two organic molecules based on merocyanine. They can self-assemble in water to form ∼1.5 nm nanoparticles. Both of them have good application potential in fluorescent anticounterfeit printing ink and pH detection. More importantly, they have excellent mitochondrial targeting ability, intracellular red light and near-infrared dual-channel imaging ability, strong antiphotobleaching ability, and in vivo and in vitro near-infrared imaging capabilities, showing superior chemotherapy capabilities and biocompatibility in the 4T1 tumor-bearing mouse model.

• Authors: Lu Zhang, Hai-Mei Li, Ji-Lei Chen, Wen-Yan She, Yi Zhao, Yang Liu, Feng-Lei Jiang, Yi Liu, Peng Jiang
• Journal: The journal of physical chemistry letters (J Phys Chem Lett) Vol. 13 Issue 4 Pg. 1090-1098 (Feb 03 2022) ISSN: 1948-7185 [Electronic] United States
• PMID: 35080405 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Benzopyrans
• Indicators and Reagents
• Indoles
• Reactive Oxygen Species
• merocyanine

Topics

• Animals
• Antineoplastic Agents (chemistry, therapeutic use)
• Apoptosis (drug effects)
• Benzopyrans (chemistry, therapeutic use)
• Cell Line, Tumor
• Fraud (prevention & control)
• Humans
• Hydrogen-Ion Concentration
• Indicators and Reagents (chemistry, therapeutic use)
• Indoles (chemistry, therapeutic use)
• Ink
• Membrane Potential, Mitochondrial (drug effects)
• Mice
• Mitochondria (drug effects)
• Nanoparticles (chemistry, therapeutic use)
• Neoplasms (drug therapy, metabolism)
• Reactive Oxygen Species (metabolism)